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【背景】针对薄荷醇在烟草应用中存在释放不均匀、稳定性差等技术难题，首次以羟丙基-β-环糊精（HP-β-CD）和珊瑚藻多糖作为复合壁材，采用分子包埋与二次物理包埋相结合的双重包埋技术，制备具有稳定缓释功能的薄荷醇双层微胶囊。【方法】利用扫描电镜和红外光谱对微胶囊的形貌和结构进行表征，结合热重分析及不同温度下薄荷醇保留率的变化考察微胶囊的稳定性，并对添加该薄荷醇微胶囊的加热卷烟进行感官质量评价。【结果】(1)薄荷醇成功包埋于珊瑚藻多糖/HP-β-CD微胶囊中，包埋率高达95.0%；(2)纯薄荷醇在156℃时完全挥发，而珊瑚藻多糖/HP-β-CD/薄荷醇微胶囊在25～300℃失重缓慢，400℃时仅失重50.0%；贮存实验显示，纯薄荷醇在25℃（3个月）和60℃（14 d）的保留率分别降至44.8%和5%，而微胶囊包埋后提升至88.0%和68.8%，稳定性显著增强；(3)在加热卷烟的抽吸过程中，纯薄荷醇的释放量从第4口开始显著下降，而珊瑚藻多糖/HP-β-CD/薄荷醇微胶囊从第1口起稳步释放，第7口达到峰值（0.098 mg/口），至第10口的释放量仍显著高于初始值，凉感均匀且稳定，有效解决了薄荷醇加热卷烟释放快速衰减的问题。
Abstract：To address the challenges of uneven release and poor stability of menthol in tobacco applications, a novel bilayer menthol microcapsule with sustained-release functionality was prepared for the first time using hydroxypropyl-β-cyclodextrin(HP-β-CD) and coralline algal polysaccharide as composite wall materials. The microcapsules were fabricated through a dual-encapsulation strategy combining molecular inclusion and secondary physical encapsulation. The morphology and structural characteristics of the microcapsules were analyzed by scanning electron microscopy and Fourier-transform infrared spectroscopy. Their thermal stability was evaluated by thermogravimetric analysis, and the retention behavior of menthol at different temperatures was systematically investigated. In addition, the sensory quality of heated tobacco products incorporated with the menthol microcapsules was assessed. The results demonstrated that:(1) Menthol was successfully encapsulated within the coralline algal polysaccharide/HP-β-CD bilayer microcapsules, achieving an encapsulation efficiency as high as 95.0%.(2) Pure menthol completely volatilized at 156℃, whereas the coralline algal polysaccharide/HP-β-CD/menthol microcapsules exhibited a gradual mass loss over the temperature range of 25-300℃, with only 50.0% weight loss at 400℃. Storage tests revealed that the retention rates of pure menthol decreased sharply to 44.8% after 3 months at 25℃ and to 5.0% after 14 days at 60℃, while encapsulation increased the retention rates to 88.0% and 68.8%, respectively, indicating significantly enhanced stability.(3) During the puff-by-puff smoking process of heated tobacco products, the release of pure menthol declined markedly from the fourth puff onward. In contrast, the coralline algal polysaccharide/HP-β-CD/menthol microcapsules exhibited a stable and sustained release from the first puff, reaching a maximum release of 0.098 mg/puff at the seventh puff. Notably, the release amount at the tenth puff remained significantly higher than the initial level, providing uniform and persistent cooling sensation. This effectively overcomes the rapid release attenuation of menthol in heated tobacco products.
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基本信息:
DOI：10.16472/j.chinatobacco.2025.T0068
中图分类号:TS426
引用信息:
[1]郑泉兴,马鹏飞,赖炜扬,等.薄荷醇缓释微胶囊的制备及其在加热卷烟中的应用[J].中国烟草学报,2026,32(01):26-34.DOI:10.16472/j.chinatobacco.2025.T0068.
基金信息:
中国烟草总公司重大科技项目(110202201043(XX-02)); 福建中烟工业有限责任公司科技项目(FJZYKJJH2022ZD023); 厦门海洋研究开发院共建项目(kfy2025-2); 厦门南方海洋研究中心项目(22CZP008HJ10); 福建省科技计划项目(2023N0037); 厦门市自然科学基金项目(3502Z202373077); 自然资源部海洋生物资源开发利用工程技术创新中心开放基金(TICMBR202305)
2025-12-18
2025-12-18
2025-12-18