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【目的】研究不同烟碱盐的热解机制及产物释放规律。【方法】以《电子烟》国标中允许添加的6种酸与烟碱合成的烟碱盐为研究对象，采用热重分析（TG）和固定床反应器结合单光子光电离飞行时间质谱（FBR-SPI-MS）方法，考察6种单组分烟碱盐和9种乙酰丙酸、苹果酸不同混合比例合成的烟碱盐的热失重行为及其热解产物释放机制。【结果】(1)烟碱盐较游离烟碱对应的热失重温度及范围均有提升，苯甲酸盐的最大失重温度最高，柠檬酸盐失重温度范围最广；(2)SPI-MS分析表明，烟碱盐热裂解能够产生烟碱、苯甲酸、乙酰丙酸等分子离子碎片；(3)不同酸与烟碱成盐后对烟碱释放影响不同，混合烟碱盐的烟碱释放温度区间随着酸碱摩尔比的增大向高温区移动。【结论】为烟碱盐的热行为和热解产物释放机制提供结论，为电子烟产品的开发提供参考。
Abstract：[Objective] This study aims to study the pyrolysis mechanisms and product release patterns of different nicotine salts. [Methods]Six types of nicotine salts synthesized from acids allowed in the "E-Cigarette" national standard and nicotine were examined using thermogravimetric analysis(TG) and a fixed bed reactor combined with single-photon photoionization time-of-flight mass spectrometry(FBR-SPI-MS) to investigate the thermal degradation behavior and pyrolysis product release mechanisms of these six single-component nicotine salts and nine different mix ratios of acetoacetate and malate nicotine salts. [Results](1) The thermal degradation temperatures and ranges of nicotine salts were higher than those of the corresponding free nicotine, with the benzoate having the highest maximum weight loss temperature and the citrate covering the widest temperature range;(2) SPI-MS analysis indicated that the thermal cracking of nicotine salts can produce molecular ion fragments such as nicotine, benzoic acid, and acetoacetic acid;(3) The interaction of different acids with nicotine to form salts had varying effects on nicotine release, with the nicotine release temperature range of mixed nicotine salts shifting to higher temperatures as the acid-base molar ratio increased. [Conclusion] The study provides insights into the thermal behavior and pyrolysis product release mechanisms of nicotine salts, offering references for the development of e-cigarette products.
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基本信息:
DOI：10.16472/j.chinatobacco.2023.T0074
中图分类号:TS411;O657.63
引用信息:
[1]管明婧,周顺,田慧娟等.基于FBR-SPI-MS法的烟碱盐热解机制及产物释放规律研究[J].中国烟草学报,2024,30(05):20-29.DOI:10.16472/j.chinatobacco.2023.T0074.
基金信息:
中国烟草总公司加热卷烟研制重大专项项目“颗粒型加热卷烟产品生产关键控制技术及效能提升研究”（110202201046(XX-05)）; 安徽中烟工业有限责任公司科研项目“烟碱衍生物的合成及在电子烟产品中的应用”（2021155）;“加热卷烟用增香胶囊的开发及应用研究”（2022155）